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Basic Drug Info
Drug Name:Lidocaine Hydrochloride
Manufacturer:Hospira, Inc.
Other Info:



Clinical Trials:


Indications and Usage
Lidocaine hydrochloride injection administered intravenously or intramuscularly, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.
Ventricular arrhythmia -- Irregular heart beat resulting from a pathologic process in the cardiac ventricles.--2004

Acute myocardial infarction --

Contraindications
Lidocaine hydrochloride is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type. Lidocaine hydrochloride should not be used in patients with Stokes-Adams syndrome, Wolff-Parkinson-White syndrome or with severe degrees of sinoatrial, atrioventricular or intraventricular block in the absence of an artificial pacemaker.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

SPONDYLOMETAEPIPHYSEAL DYSPLASIA, SHORT LIMB-HAND TYPE --

Adams-Stokes Syndrome -- A condition of fainting spells caused by heart block, often an atrioventricular block, that leads to BRADYCARDIA and drop in CARDIAC OUTPUT. When the cardiac output becomes too low, the patient faints (SYNCOPE). In some cases, the syncope attacks are transient and in others cases repetitive and persistent.

Wolff-Parkinson-White Syndrome -- A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulse conducts to the HEART VENTRICLES via an accessory pathway located between the wall of the right or left atria and the ventricles, known as the bundle of Kent. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.

Intraventricular conduction defect --

Warnings

IN ORDER TO MANAGE POSSIBLE ADVERSE REACTIONS, RESUSCITATIVE EQUIPMENT, OXYGEN AND OTHER RESUSCITATIVE DRUGS SHOULD BE IMMEDIATELY AVAILABLE WHEN LIDOCAINE HYDROCHLORIDE INJECTION IS USED.

THE 10% AND 20% CONCENTRATED SOLUTIONS MUST NOT BE INJECTED UNDILUTED. See DOSAGE AND ADMINISTRATION.

Systemic toxicity may result in manifestations of central nervous system depression (sedation) or irritability (twitching), which may progress to frank convulsions accompanied by respiratory depression and/or arrest.

Early recognition of premonitory signs, assurance of adequate oxygenation and, where necessary, establishment of artificial airway with ventilatory support are essential to management of this problem.

Should convulsions persist despite ventilatory therapy with oxygen, small increments of anticonvulsant drugs may be used intravenously.

Examples of such agents include benzodiazepines (e.g., diazepam), ultrashort-acting barbiturates (e.g., thiopental or thiamylal) or a short-acting barbiturate (e.g., pentobarbital or secobarbital).

If the patient is under anesthesia, a short-acting muscle relaxant (e.g., succinylcholine) may be used.

Longer acting drugs should be used only when recurrent convulsions are evidenced.

Should circulatory depression occur, vasopressors may be used.

Constant electrocardiographic monitoring is essential to the proper administration of lidocaine hydrochloride. Signs of excessive depression of cardiac electrical activity such as sinus node dysfunction, prolongation of the P-R interval and QRS complex or the appearance or aggravation of arrhythmias, should be followed by flow adjustment and, if necessary, prompt cessation of the intravenous infusion of this agent. Occasionally, acceleration of ventricular rate may occur when lidocaine hydrochloride is administered to patients with atrial flutter or fibrillation.
Branded Drugs
The following US Branded drugs contain Lidocaine Hydrochloride


DUOCAINE -- AMPHASTAR PHARMACEUTICALS INC

DECADRON W/ XYLOCAINE -- MERCK AND CO INC

EMBOLEX -- NOVARTIS PHARMACEUTICALS CORP

LIGNOSPAN FORTE -- DEPROCO INC

LIGNOSPAN STANDARD -- DEPROCO INC

ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE -- CARLISLE LABORATORIES INC

LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE -- EASTMAN KODAK CO

LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE -- ELKINS SINN DIV AH ROBINS CO INC

LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE -- GRAHAM CHEMICAL CO

LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE -- ABBOTT LABORATORIES PHARMACEUTICAL PRODUCTS DIV

LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE -- BEL MAR LABORATORIES INC

LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE -- DELL LABORATORIES INC

LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE -- INTERNATIONAL MEDICATION SYSTEM

LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE -- WATSON LABORATORIES INC

LIDOCATON -- PHARMATON LTD

OCTOCAINE -- SEPTODONT INC

XYLOCAINE DENTAL WITH EPINEPHRINE -- DENTSPLY PHARMACEUTICAL

XYLOCAINE W/ EPINEPHRINE -- APP PHARMACEUTICALS LLC

XYLOCAINE W/ EPINEPHRINE -- ASTRAZENECA LP

LIDOSITE TOPICAL SYSTEM KIT -- VYTERIS INC

IONTOCAINE -- IOMED INC

LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE -- EMPI INC

AKTEN -- AKORN INC

ALPHACAINE HYDROCHLORIDE -- CARLISLE LABORATORIES INC

LIDOCAINE HYDROCHLORIDE 0.1% AND DEXTROSE 5% IN PLASTIC CONTAINER -- BAXTER HEALTHCARE CORP

LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER -- B BRAUN MEDICAL INC

LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER -- BAXTER HEALTHCARE CORP

LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER -- ABBOTT LABORATORIES PHARMACEUTICAL PRODUCTS DIV

LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER -- B BRAUN MEDICAL INC

LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER -- BAXTER HEALTHCARE CORP

LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% IN PLASTIC CONTAINER -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER -- B BRAUN MEDICAL INC

LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER -- BAXTER HEALTHCARE CORP

LIDOCAINE HYDROCHLORIDE 0.8% IN DEXTROSE 5% IN PLASTIC CONTAINER -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE IN PLASTIC CONTAINER -- ABRAXIS PHARMACEUTICAL PRODUCTS

LIDOCAINE HYDROCHLORIDE IN PLASTIC CONTAINER -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE -- ABRAXIS PHARMACEUTICAL PRODUCTS

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE -- BAXTER HEALTHCARE CORP ANESTHESIA AND CRITICAL CARE

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE -- HOSPIRA INC

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE -- INTERNATIONAL MEDICATION SYSTEM

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE IN PLASTIC CONTAINER -- HOSPIRA INC

LIDOPEN -- MERIDIAN MEDICAL TECHNOLOGIES INC

XYLOCAINE -- APP PHARMACEUTICALS LLC

XYLOCAINE -- ASTRAZENECA LP

XYLOCAINE 4% PRESERVATIVE FREE -- APP PHARMACEUTICALS LLC

XYLOCAINE DENTAL -- DENTSPLY PHARMACEUTICAL

XYLOCAINE PRESERVATIVE FREE -- APP PHARMACEUTICALS LLC

LIDOCAINE HYDROCHLORIDE 5% AND DEXTROSE 7.5% -- HOSPIRA INC

XYLOCAINE 1.5% W/ DEXTROSE 7.5% -- APP PHARMACEUTICALS LLC

XYLOCAINE 5% W/ GLUCOSE 7.5% -- ASTRAZENECA LP

ANESTACON -- POLYMEDICA INDUSTRIES INC

LIDOCAINE HYDROCHLORIDE VISCOUS -- ACTAVIS MID ATLANTIC LLC

LIDOCAINE HYDROCHLORIDE VISCOUS -- INTERNATIONAL MEDICATION SYSTEMS LTD

LIDOCAINE HYDROCHLORIDE VISCOUS -- VINTAGE PHARMACEUTICALS LLC

LIDOCAINE VISCOUS -- ROXANE LABORATORIES INC

XYLOCAINE VISCOUS -- APP PHARMACEUTICALS LLC

LARYNG-O-JET KIT -- INTERNATIONAL MEDICATION SYSTEM

LARYNGOTRACHEAL ANESTHESIA KIT -- KENDALL CO

LTA II KIT -- HOSPIRA INC

PEDIATRIC LTA KIT -- ABBOTT LABORATORIES PHARMACEUTICAL PRODUCTS DIV

PEDIATRIC LTA KIT -- HOSPIRA INC

ZINGO -- ANESIVA INC

TERRAMYCIN -- PFIZER LABORATORIES DIV PFIZER INC


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