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Basic Drug Info
Drug Name:Spironolactone
Manufacturer:Sandoz Inc.
Other Info:

Rev.

06-2006M7019Sandoz Inc.Princeton, NJ 08540



Clinical Trials:


Indications and Usage
Spironolactone is indicated in the management of:
Contraindications
Spironolactone is contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia.
Anuria -- Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present.

Acute Kidney Insufficiency -- Conditions in which the function of KIDNEYS deteriorates suddenly in a matter of days or even hours. It is characterized by the sudden drop in GLOMERULAR FILTRATION RATE; (GMR). The most severe stage is when the GFR drops below 15 ml per min (ACUTE KIDNEY FAILURE).

Warnings

Potassium supplementation, either in the form of medication or as a diet rich in potassium, should not ordinarily be given in association with spironolactone therapy.

Excessive potassium intake may cause hyperkalemia in patients receiving spironolactone (see PRECAUTIONS: General).

Spironolactone should not be administered concurrently with other potassium-sparing diuretics.

Spironolactone, when used with ACE inhibitors or indomethacin, even in the presence of a diuretic, has been associated with severe hyperkalemia.

Extreme caution should be exercised when spironolactone is given concomitantly with these drugs.Spironolactone should be used with caution in patients with impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma.Lithium generally should not be given with diuretics (see PRECAUTIONS: Drug Interactions).
Branded Drugs
The following US Branded drugs contain Spironolactone


ALDACTAZIDE -- GD SEARLE LLC

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE -- ASCOT HOSP PHARMACEUTICALS INC DIV TRAVENOL LABORATORIES INC

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE -- MUTUAL PHARMACEUTICAL CO INC

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE -- MYLAN PHARMACEUTICALS INC

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE -- PUREPAC PHARMACEUTICAL CO

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE -- SANDOZ INC

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE -- SUPERPHARM CORP

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE -- WATSON LABORATORIES INC

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- IVAX PHARMACEUTICALS INC

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- LEDERLE LABORATORIES DIV AMERICAN CYANAMID CO

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- PARKE DAVIS DIV WARNER LAMBERT CO

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- PUREPAC PHARMACEUTICAL CO

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- UPSHER SMITH LABORATORIES INC

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- USL PHARMA INC

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- VANGARD LABORATORIES INC DIV MIDWAY MEDICAL CO

SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE -- WATSON LABORATORIES INC

ALDACTONE -- GD SEARLE LLC


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