06-2006M7019Sandoz Inc.Princeton, NJ 08540
Spironolactone is indicated in the management of:
Spironolactone is contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia.
-- Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present.
Acute Kidney Insufficiency
-- Conditions in which the function of KIDNEYS deteriorates suddenly in a matter of days or even hours. It is characterized by the sudden drop in GLOMERULAR FILTRATION RATE; (GMR). The most severe stage is when the GFR drops below 15 ml per min (ACUTE KIDNEY FAILURE).
Potassium supplementation, either in the form of medication or as a diet rich in potassium, should not ordinarily be given in association with spironolactone therapy.
Excessive potassium intake may cause hyperkalemia in patients receiving spironolactone (see PRECAUTIONS: General).
Spironolactone should not be administered concurrently with other potassium-sparing diuretics.
Spironolactone, when used with ACE inhibitors or indomethacin, even in the presence of a diuretic, has been associated with severe hyperkalemia.
Extreme caution should be exercised when spironolactone is given concomitantly with these drugs.Spironolactone should be used with caution in patients with impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma.Lithium generally should not be given with diuretics (see PRECAUTIONS: Drug Interactions).
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