PROSTIN E2 Vaginal Suppository is indicated for the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period.PROSTIN E2 is also indicated for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period.PROSTIN E2 is indicated in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

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Missed abortion -- The retention in the UTERUS of a dead FETUS two months or more after its DEATH.

Fetal Death -- Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.

Hypersensitivity to dinoprostoneAcute pelvic inflammatory diseasePatients with active cardiac, pulmonary, renal, or hepatic disease

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Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Liver diseases -- Pathological processes of the LIVER.

Dinoprostone, as with other potent oxytocic agents, should be used only with strict adherence to recommended dosages.

Dinoprostone should be used by medically trained personnel in a hospital which can provide immediate intensive care and acute surgical facilities.