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Basic Drug Info
Drug Name:Mexiletine Hydrochloride
Manufacturer:TEVA PHARMACEUTICALS USA
Other Info:



Clinical Trials:


Indications and Usage

Mexiletine hydrochloride capsules are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Because of the proarrhythmic effects of mexiletine, its use with lesser arrhythmias is generally not recommended.

Treatment of patients with asymptomatic ventricular premature contractions should be avoided.Initiation of mexiletine treatment, as with other antiarrhythmic agents used to treat life-threatening arrhythmias, should be carried out in the hospital.Antiarrhythmic drugs have not been shown to enhance survival in patients with ventricular arrhythmias.
Ventricular arrhythmia -- Irregular heart beat resulting from a pathologic process in the cardiac ventricles.--2004

Sustained Ventricular Tachycardia -- An electrocardiographic finding of ventricular tachycardia greater than 30 seconds in duration.

cardiac arrhythmia -- any variation from the normal rhythm or rate of the heart beat.

Premature ventricular contractions -- A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.

Contraindications
Mexiletine hydrochloride capsules are contraindicated in the presence of cardiogenic shock or pre-existing second-or third-degree AV block (if no pacemaker is present).
Cardiogenic shock -- Shock resulting from diminution of cardiac output in heart disease.

Complete atrioventricular block -- Complete failure of atrial electrical impulse conduction through the AV node to the ventricles.

Branded Drugs
The following US Branded drugs contain Mexiletine Hydrochloride


MEXITIL -- BOEHRINGER INGELHEIM


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