LANOXIN is indicated for the treatment of mild to moderate
LANOXIN increases left ventricular ejection fraction and improves
heart failure symptoms as evidenced by exercise capacity and heart failure-related
hospitalizations and emergency care, while having no effect on mortality.
Where possible, LANOXIN should be used with a diuretic and an angiotensin-converting
enzyme inhibitor, but an optimal order for starting these 3 drugs cannot
-- inability of the heart to pump blood at an adequate rate to fill tissue metabolic requirements or the ability to do so only at an elevated filling pressure.
-- An indication that a person has a condition or disease. Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.
Digitalis glycosides are contraindicated in patients with
ventricular fibrillation or in patients with a known hypersensitivity to digoxin.
A hypersensitivity reaction to other digitalis preparations usually constitutes
a contraindication to digoxin.
-- A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
-- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Because digoxin slows sinoatrial and AV conduction, the
drug commonly prolongs the PR interval.
The drug may cause severe sinus bradycardia
or sinoatrial block in patients with pre-existing sinus node disease and may
cause advanced or complete heart block in patients with pre-existing incomplete
In such patients consideration should be given to the insertion
of a pacemaker before treatment with digoxin.
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