(see also Boxed
WARNING)Ketorolac tromethamine is CONTRAINDICATED in patients with active
peptic ulcer disease, in patients with recent gastrointestinal
bleeding or perforation and in patients with a history of peptic
ulcer disease or gastrointestinal bleeding.Ketorolac tromethamine is CONTRAINDICATED in patients with
advanced renal impairment or in patients at risk for renal failure
due to volume depletion (see WARNINGS for correction of volume depletion).Ketorolac tromethamine is CONTRAINDICATED in labor and delivery
because, through its prostaglandin synthesis inhibitory effect, it
may adversely affect fetal circulation and inhibit uterine
contractions, thus increasing the risk of uterine hemorrhage.The use of ketorolac tromethamine is CONTRAINDICATED in nursing
mothers because of the potential adverse effects of
prostaglandin-inhibiting drugs on neonates.Ketorolac tromethamine is CONTRAINDICATED in patients with
previously demonstrated hypersensitivity to ketorolac tromethamine,
or allergic manifestations to aspirin or other nonsteroidal
anti-inflammatory drugs (NSAIDs).Ketorolac tromethamine is CONTRAINDICATED as prophylactic
analgesic before any major surgery and is CONTRAINDICATED
intraoperatively when hemostasis is critical because of the
increased risk of bleeding.Ketorolac tromethamine inhibits platelet function and is,
therefore, CONTRAINDICATED in patients with suspected or confirmed
cerebrovascular bleeding, hemorrhagic diathesis, incomplete
hemostasis and those at high risk of bleeding (see WARNINGS and PRECAUTIONS).Ketorolac tromethamine is CONTRAINDICATED in patients currently receiving ASA or NSAIDs because of the cumulative risks of inducing
serious NSAID-related adverse events.Ketorolac Tromethamine Injection is CONTRAINDICATED for neuraxial
(epidural or intrathecal) administration due to its alcohol content.The concomitant use of ketorolac tromethamine and probenecid is
CONTRAINDICATED.
Peptic Ulcer -- Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Active Peptic Ulcer --
Disease -- A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.
Gastrointestinal Hemorrhage -- Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Kidney Failure -- A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal failure, either acute (KIDNEY FAILURE, ACUTE) or chronic (KIDNEY FAILURE, CHRONIC), requires HEMODIALYSIS.
Uterine hemorrhage -- Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.
Adverse effects -- Problems that occur when treatment affects tissues or organs other than the ones meant to be affected by the treatment. Common side effects of cancer treatment are fatigue, pain, nausea, vomiting, decreased blood cell counts, hair loss, and mouth sores.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Hemorrhagic Disorders -- spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (vascular hemostatic disorders).
NIH - Clinical Trials