|Drug Name:||Nicardipine Hydrochloride|
|Manufacturer:||TEVA PHARMACEUTICALS USA|
Nicardipine hydrochloride capsules are indicated for the management of patients with chronic stable angina (effort-associated angina).
They may be used alone or in combination with beta-blockers.
-- The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Nicardipine hydrochloride capsules are contraindicated in patients with hypersensitivity to the drug.Because part of the effect of nicardipine is secondary to reduced afterload, the drug is also contraindicated in patients with advanced aortic stenosis.
Reduction of diastolic pressure in these patients may worsen rather than improve myocardial oxygen balance.
-- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Aortic Valve Stenosis
-- A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
About 7% of patients in short term placebo-controlled angina trials have developed increased frequency, duration or severity of angina on starting nicardipine or at the time of dosage increases, compared with 4% of patients on placebo.
Comparisons with beta-blockers also show a greater frequency of increased angina, 4% vs 1%.
The mechanism of this effect has not been established.
(See ADVERSE REACTIONS.)
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