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Basic Drug Info
Drug Name:Acyclovir
Manufacturer:TEVA PHARMACEUTICALS USA
Other Info:Acyclovir suspension was shown to be bioequivalent to acyclovir capsules (n = 20) and 1 acyclovir 800 mg tablet was shown to be bioequivalent to 4 acyclovir 200 mg capsules (n = 24).



Clinical Trials:


Indications and Usage
Acyclovir is indicated for the acute treatment of herpes zoster (shingles).
Herpes zoster disease -- An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)

Contraindications
Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

Acyclovir capsules and tablets are intended for oral ingestion only.

Renal failure, in some cases resulting in death, has been observed with acyclovir therapy (see ADVERSE REACTIONS, Observed During Clinical Practice and OVERDOSAGE).

Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), which has resulted in death, has occurred in immunocompromised patients receiving acyclovir therapy.
Branded Drugs
The following US Branded drugs contain Acyclovir


ZOVIRAX -- GLAXOSMITHKLINE


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