The total management of anxiety, tension, and psychomotor agitation in conditions of emotional stress requires in most instances a combined approach of psychotherapy and chemotherapy.
Hydroxyzine has been found to be particularly useful for this latter phase of therapy in its ability to render the disturbed patient more amenable to psychotherapy in long term treatment of the psychoneurotic and psychotic, although it should not be used as the sole treatment of psychosis or of clearly demonstrated cases of depression.Hydroxyzine is also useful in alleviating the manifestations of anxiety and tension as in the preparation for dental procedures and in acute emotional problems.
It has also been recommended for the management of anxiety associated with organic disturbances and as adjunctive therapy in alcoholism and allergic conditions with strong emotional overlay, such as in asthma, chronic urticaria, and pruritus.VISTARIL (hydroxyzine hydrochloride) Intramuscular Solution is useful in treating the following types of patients when intramuscular administration is indicated:The acutely disturbed or hysterical patient.The acute or chronic alcoholic with anxiety withdrawal symptoms or delirium tremens.As pre- and postoperative and pre- and postpartum adjunctive medication to permit reduction in narcotic dosage, allay anxiety and control emesis.VISTARIL (hydroxyzine hydrochloride) has also demonstrated effectiveness in controlling nausea and vomiting, excluding nausea and vomiting of pregnancy.
(See Contraindications.)In prepartum states, the reduction in narcotic requirement effected by hydroxyzine is of particular benefit to both mother and neonate.Hydroxyzine benefits the cardiac patient by its ability to allay the associated anxiety and apprehension attendant to certain types of heart disease.
Hydroxyzine is not known to interfere with the action of digitalis in any way and may be used concurrently with this agent.The effectiveness of hydroxyzine in long term use, that is, more than 4 months, has not been assessed by systematic clinical studies.The physician should reassess periodically the usefulness of the drug for the individual patient.
Hydroxyzine hydrochloride intramuscular solution is intended only for intramuscular administration and should not, under any circumstances, be injected subcutaneously, intra-arterially, or intravenously.This drug is contraindicated for patients who have shown a previous hypersensitivity to it.Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit, induced fetal abnormalities in the rat at doses substantially above the human therapeutic range.
Clinical data in human beings are inadequate to establish safety in early pregnancy.Until such data are available, hydroxyzine is contraindicated in early pregnancy.