Basic Drug Info
Drug Name:Hydralazine Hydrocloride
Other Info:

Treatment: There is no specific antidote.Support of the cardiovascular system is of primary importance.

Shock should be treated with plasma expanders.

If possible, vasopressors should not be given, but if a vasopressor is required, care should be taken not to precipitate or aggravate cardiac arrhythmia.

Tachycardia responds to beta blockers.

Digitalization may be necessary, and renal function should be monitored and supported as required.No experience has been reported with extracorporeal or peritoneal dialysis.

Clinical Trials:

Indications and Usage
Severe essential hypertension when the drug cannot be given orally or when there is an urgent need to lower blood pressure.
Essential Hypertension -- hypertension occurring without preexisting renal disease or known organic cause.

Hypersensitivity to hydralazine; coronary artery disease; mitral valvular rheumatic heart disease.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Rheumatism -- Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.


In a few patients hydralazine may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis.

In such patients hydralazine should be discontinued unless the benefit-to-risk determination requires continued antihypertensive therapy with this drug.

Symptoms and signs usually regress when the drug is discontinued but residua have been detected many years later.

Long-term treatment with steroids may be necessary.

(See PRECAUTIONS, Laboratory Tests.)

This web-site is for informational purposes only and is not intended as a substitute for advice from your doctor. It should not to be used for self-diagnosis or treatment.