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Basic Drug Info
Drug Name:Isosorbide Mononitrate
Manufacturer:Actavis Elizabeth LLC
Other Info:



Clinical Trials:


Indications and Usage

Isosorbide mononitrate tablets are indicated for the prevention and treatment of angina pectoris due to coronary artery disease.

The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.
Angina Pectoris -- The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.

Coronary Artery Disease -- Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

Contraindications

Allergic reactions to organic nitrates are extremely rare, but they do occur.

Isosorbide mononitrate is contraindicated in patients who are allergic to it.
Allergic Reaction --

Warnings

Amplification of the vasodilatory effects of isosorbide mononitrate by sildenafil can result in severe hypotension.

The time course and dose dependence of this interaction have not been studied.

Appropriate supportive care has not been studied, but it seems reasonable to treat this as a nitrate overdose, with elevation of the extremities and with central volume expansion.The benefits of isosorbide mononitrate in patients with acute myocardial infarction or congestive heart failure have not been established.

Because the effects of isosorbide mononitrate are difficult to terminate rapidly, this drug is not recommended in these settings.If isosorbide mononitrate is used in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of hypotension and tachycardia.
Branded Drugs
The following US Branded drugs contain Isosorbide Mononitrate


IMDUR -- SCHERING PLOUGH CORP

ISMO -- PROMIUS PHARMA LLC

MONOKET -- SCHWARZ GMBH


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