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Basic Drug Info
Drug Name:Verapamil Hydrochloride
Manufacturer:Watson Laboratories, Inc.
Other Info:Rx only



Clinical Trials:


Indications and Usage
Verapamil Hydrochloride Tablets are indicated for the treatment of the following:Angina1. Angina at rest including:– Vasospastic (Prinzmetal’s variant) angina– Unstable (crescendo, pre-infarction) angina2. Chronic stable angina (classic effort-associated angina)Arrhythmias1. In association with digitalis for the control of ventricular rate at rest and during stress in patients with chronic atrial flutter and/or atrial fibrillation (see WARNINGS; Accessory Bypass Tract)2. Prophylaxis of repetitive paroxysmal supraventricular tachycardiaEssential Hypertension
Angina Pectoris -- The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.

Atrial Fibrillation -- Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.

Paroxysmal Hypertension --

Contraindications

Verapamil Hydrochloride Tablets are contraindicated in:1.

Severe left ventricular dysfunction (see WARNINGS)2.

Hypotension (systolic pressure less than 90 mm Hg) or cardiogenic shock3.

Sick sinus syndrome (except in patients with a functioning artificial ventricular pacemaker)4.

Second-or-third-degree AV block (except in patients with a functioning artificial ventricular pacemaker)5.

Patients with atrial flutter or atrial fibrillation and an accessory bypass tract (e.g., Wolff-Parkinson-White, Lown-Ganong-Levine syndromes).

(see WARNINGS)6.

Patients with known hypersensitivity to verapamil hydrochloride.
Left Ventricular Dysfunction -- A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.

Sick Sinus Syndrome -- A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.

Complete atrioventricular block -- Complete failure of atrial electrical impulse conduction through the AV node to the ventricles.

Atrial Flutter -- Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).

Atrial Fibrillation -- Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.

Lown-Ganong-Levine Syndrome -- A form of ventricular pre-excitation characterized by a short PR interval and a normal QRS complex. In this syndrome, the atrial impulse conducts via the James fibers which connect the atrium to BUNDLE OF HIS bypassing the upper ATRIOVENTRICULAR NODE. HEART VENTRICLES are depolarized normally through the His-Purkinje system.

Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

Verapamil has a negative inotropic effect, which in most patients is compensated by its afterload reduction (decreased systemic vascular resistance) properties without a net impairment of ventricular performance.

In clinical experience with 4,954 patients, 87 (1.8%) developed congestive heart failure or pulmonary edema.

Verapamil should be avoided in patients with severe left ventricular dysfunction (e.g., ejection fraction less than 30%) or moderate to severe symptoms of cardiac failure and in patients with any degree of ventricular dysfunction if they are receiving a beta-adrenergic blocker (see Drug interactions).

Patients with milder ventricular dysfunction should, if possible, be controlled with optimum doses of digitalis and/or diuretics before verapamil treatment.

(Note interactions with digoxin under PRECAUTIONS.)
Branded Drugs
The following US Branded drugs contain Verapamil Hydrochloride


TARKA -- ABBOTT LABORATORIES PHARMACEUTICAL PRODUCTS DIV

VERELAN -- ELAN DRUG DELIVERY INC

VERELAN PM -- ELAN DRUG DELIVERY INC

CALAN -- GD SEARLE LLC

ISOPTIN -- FSC LABORATORIES INC

COVERA-HS -- GD SEARLE LLC

ISOPTIN SR -- RANBAXY LABORATORIES INC


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