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Basic Drug Info
Drug Name:Lactulose
Manufacturer:Roxane Laboratories
Other Info:

Dialysis data are not available for lactulose.

Its molecular similarity to sucrose, however, would suggest it should be dialyzable.



Clinical Trials:


Indications and Usage

For the treatment of constipation.

In patients with a history of chronic constipation, lactulose solution therapy increases the number of bowel movements per day and the number of days on which bowel movements occur.
Constipation -- Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.

Contraindications
Since lactulose solution contains galactose (less than 1.6 g/15 mL), it is contraindicated in patients who require a low galactose diet.
Warnings

A theoretical hazard may exist for patients being treated with lactulose solution who may be required to undergo electrocautery procedures during proctoscopy or colonoscopy.

Accumulation of H2 gas in significant concentration in the presence of an electrical spark may result in an explosive reaction.

Although this complication has not been reported with lactulose, patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution.

Insufflation of CO2 as an additional safeguard may be pursued but is considered to be a redundant measure.
Branded Drugs
The following US Branded drugs contain Lactulose


CHRONULAC -- SANOFI AVENTIS US LLC

CONSTILAC -- ALRA LABORATORIES INC

CONSTULOSE -- ACTAVIS MID ATLANTIC LLC

DUPHALAC -- SOLVAY PHARMACEUTICALS

EVALOSE -- TEVA PHARMACEUTICALS USA

LAXILOSE -- NOSTRUM LABORATORIES INC

ACILAC -- NOSTRUM LABORATORIES INC

CEPHULAC -- SANOFI AVENTIS US LLC

CHOLAC -- ALRA LABORATORIES INC

ENULOSE -- ACTAVIS MID ATLANTIC LLC

GENERLAC -- MORTON GROVE PHARMACEUTICALS INC

HEPTALAC -- TEVA PHARMACEUTICALS USA

PORTALAC -- SOLVAY PHARMACEUTICALS


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