|Drug Name:||Diltia XT|
|Manufacturer:||Watson Pharma, Inc.|
Sublingual Nitroglycerin may be taken as required to abort acute anginal attacks during diltiazem hydrochloride therapy.Prophylactic Nitrate Therapy— Diltiazem hydrochloride may be safely co-administered with short- and long-acting nitrates.Beta-blockers.
(See WARNINGS and PRECAUTIONS.)Antihypertensives— Diltiazem hydrochloride has an additive antihypertensive effect when used with other antihypertensive agents.Therefore, the dosage of diltiazem hydrochloride or the concomitant antihypertensives may need to be adjusted when adding one to the other.
Diltiazem hydrochloride extended-release capsules USP (Once-a-day dosage) are indicated for the treatment of hypertension.Diltiazem hydrochloride may be used alone or in combination with other antihypertensive medications, such as diuretics.Diltiazem hydrochloride extended-release capsules USP (Once-a-day dosage) are indicated for the management of chronic stable angina.
Diltiazem hydrochloride prolongs AV node refractory periods without significantly prolonging sinus node recovery time, except in patients with sick sinus syndrome.
This effect may rarely result in abnormally slow heart rates (particularly in patients with sick sinus syndrome) or second, or third degree AV block (22 of 10,119 patients, or 0.2%); 41% of these 22 patients were receiving concomitant ?-adrenoceptor antagonists versus 17% of the total group.
Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction.A patient with Prinzmetal's angina developed periods of asystole (2 to 5 seconds) after a single 60 mg dose of diltiazem.