|Drug Name:||Oxycodone Hydrochloride|
Dispense in tight, light-resistant container with child-resistant closure.Protect from moisture.
Protect from light.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].
is a registered trademark of Mallinckrodt Inc.Mallinckrodt Inc.St.Louis, MO 63134 U.S.A.tycoHealthcareMallinckrodtPrinted in U.S.A.Rev 081007
Oxycodone hydrochloride tablets are contraindicated in patients with known hypersensitivity to oxycodone, or in any situation where opioids are contraindicated.
This includes patients with significant respiratory depression (in unmonitored settings or the absence of resuscitative equipment) and patients with acute or severe bronchial asthma or hypercarbia.Oxycodone hydrochloride tablets are contraindicated in any patient who has or is suspected of having paralytic ileus.
Respiratory depression is the chief hazard from all opioid agonist preparations.
Respiratory depression occurs most frequently in elderly or debilitated patients, usually following large initial doses in non-tolerant patients, or when opioids are given in conjunction with other agents that depress respiration.Oxycodone hydrochloride tablets should be used with extreme caution in patients with significant chronic obstructive pulmonary disease or cor pulmonale, and in patients having substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression.
In such patients, even usual therapeutic doses of oxycodone hydrochloride tablets may decrease respiratory drive to the point of apnea.In these patients alternative non-opioid analgesics should be considered, and opioids should be employed only under careful medical supervision at the lowest effective dose.