Basic Drug Info
Drug Name:ZYMAR
Manufacturer:Allergan, Inc.
Other Info:

Ophthalmic Use: The most frequently reported adverse events in the overall study population were conjunctival irritation, increased lacrimation, keratitis, and papillary conjunctivitis.

These events occurred in approximately 5-10% of patients.

Other reported reactions occurring in 1-4% of patients were chemosis, conjunctival hemorrhage, dry eye, eye discharge, eye irritation, eye pain, eyelid edema, headache, red eye, reduced visual acuity and taste disturbance.

Clinical Trials:

Indications and Usage
ZYMAR® solution is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms:Aerobic Gram-Positive Bacteria:Corynebacterium propinquumStaphylococcus aureusStaphylococcus epidermidisStreptococcus mitisStreptococcus pneumoniaeAerobic Gram-Negative Bacteria:Haemophilus influenzae
Bacterial conjunctivitis -- Purulent infections of the conjunctiva by several species of gram-negative, gram-positive, or acid-fast organisms. Some of the more commonly found genera causing conjunctival infections are Haemophilus, Streptococcus, Neisseria, and Chlamydia.

ZYMAR® solution is contraindicated in patients with a history of hypersensitivity to gatifloxacin, to other quinolones, or to any of the components in this medication.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.


NOT FOR INJECTION.ZYMAR® solution should not be injected subconjunctivally, nor should it be introduced directly into the anterior chamber of the eye.In patients receiving systemic quinolones, including gatifloxacin, serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported.

Some reactions were accompanied by cardiovascular collapse, loss of consciousness, angioedema (including laryngeal, pharyngeal or facial edema), airway obstruction, dyspnea, urticaria, and itching.

If an allergic reaction to gatifloxacin occurs, discontinue the drug.

Serious acute hypersensitivity reactions may require immediate emergency treatment.

Oxygen and airway management should be administered as clinically indicated.

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