COREG is contraindicated in the following conditions:Bronchial asthma or related bronchospastic conditions.
Deaths from status asthmaticus have been reported following single
doses of COREG.Second- or third-degree AV blockSick sinus syndromeSevere bradycardia (unless a permanent pacemaker
is in place)Patients with cardiogenic shock or who have decompensated
heart failure requiring the use of intravenous inotropic therapy.
Such patients should first be weaned from intravenous therapy before
initiating COREG.Patients with severe hepatic impairment Patients with a history
of a serious hypersensitivity reaction (e.g., Stevens-Johnson syndrome,
anaphylactic reaction, angioedema) to carvedilol, any of the components
of COREG, or to COREG CR
-- A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
-- A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.
-- A heart rate of less than 60 beats per minute, with its origin in the sinus node. (NCI)
-- Shock resulting from diminution of cardiac output in heart disease.
-- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
-- A variant of bullous erythema multiforme. It ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic disorder. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis, and sometimes blindness. The cause of the disease is unknown.
-- Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.