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Basic Drug Info
Drug Name:Nitroglycerin
Manufacturer:MYLAN PHARMACEUTICALS INC.
Other Info:MYLAN PHARMACEUTICALS INC.Morgantown, WV 26505PL:NTG:R9



Clinical Trials:


Indications and Usage

Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.

The onset of action of transdermal nitroglycerin is not sufficiently rapid for this product to be useful in aborting an acute attack.
Angina Pectoris -- The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.

Coronary Artery Disease -- Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

Contraindications

Use of Nitroglycerin Transdermal Systems is contraindicated in patients using Viagra® (sildenafil) because sildenafil may amplify the vasodilatory effects of Nitroglycerin Transdermal Systems resulting in severe hypotension.Allergic reactions to organic nitrates are extremely rare, but they do occur.

Nitroglycerin is contraindicated in patients who are allergic to it.

Allergy to the adhesives used in nitroglycerin patches has also been reported, and it similarly constitutes a contraindication to the use of this product.
Allergic Reaction --

Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Immediate hypersensitivity -- Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

Warnings

Amplification of the vasodilatory effects of Nitroglycerin Transdermal Systems by sildenafil may result in severe hypotension.

The time course and dose dependence of this interaction have not been studied.

Appropriate supportive care has not been studied, but it seems reasonable to treat this as a nitrate overdose, with elevation of the extremities and with central volume expansion.The benefits of transdermal nitroglycerin in patients with acute myocardial infarction or congestive heart failure have not been established.

If one elects to use nitroglycerin in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of hypotension and tachycardia.A cardioverter/defibrillator should not be discharged through a paddle electrode that overlies a nitroglycerin transdermal patch.

The arcing that may be seen in this situation is harmless in itself, but it may be associated with local current concentration that can cause damage to the paddles and burns to the patient.
Branded Drugs
The following US Branded drugs contain Nitroglycerin


NITROMIST -- NOVADEL PHARMA INC

NITROLINGUAL -- POHL BOSKAMP

MINITRAN -- GRACEWAY PHARMACEUTICALS LLC

NITRO-DUR -- KEY PHARMACEUTICALS INC SUB SCHERING PLOUGH CORP

TRANSDERM-NITRO -- NOVARTIS PHARMACEUTICALS CORP

NITRO IV -- G POHL BOSKAMP GMBH AND CO

NITRO-BID -- SANOFI AVENTIS US LLC

NITROGLYCERIN IN DEXTROSE 5% -- BAXTER HEALTHCARE CORP

NITROGLYCERIN IN DEXTROSE 5% -- HOSPIRA INC

NITROL -- RORER PHARMACEUTICAL CORP SUB RORER GROUP

NITRONAL -- G POHL BOSKAMP GMBH AND CO

NITROSTAT -- PARKE DAVIS DIV WARNER LAMBERT CO

TRIDIL -- HOSPIRA INC

NITROLINGUAL PUMPSPRAY -- POHL BOSKAMP

NITROSTAT -- PFIZER PHARMACEUTICALS LTD


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