INVERSINE should not be used in mild, moderate, labile hypertension and may prove unsuitable in uncooperative patients.
It is contraindicated in coronary insufficiency or recent myocardial infarction.INVERSINE should be given with great discretion, if at all, when renal insufficiency is manifested by a rising or elevated BUN.
The drug is contraindicated in uremia.
Patients receiving antibiotics and sulfonamides should generally not be treated with ganglion blockers.Other contraindications are glaucoma, organic pyloric stenosis or hypersensitivity to the product.
Mecamylamine, a secondary amine, readily penetrates into the brain and thus may produce central nervous system effects.
Tremor, choreiform movements, mental aberrations, and convulsions may occur rarely.
These have occurred most often when large doses of INVERSINE were used, especially in patients with cerebral or renal insufficiency.When ganglion blockers or other potent antihypertensive drugs are discontinued suddenly, hypertensive levels return.
In patients with malignant hypertension and others, this may occur abruptly and may cause fatal cerebral vascular accidents or acute congestive heart failure.
When INVERSINE is withdrawn, this should be done gradually and other antihypertensive therapy usually must be substituted.On the other hand, the effects of INVERSINE sometimes may last from hours to days after therapy is discontinued.