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Basic Drug Info
Drug Name:Carisoprodol
Manufacturer:Actavis Totowa LLC
Other Info:



Clinical Trials:


Indications and Usage
Carisoprodol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.  The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.  Carisoprodol does not directly relax tense skeletal muscles in man.
Sensory Discomfort -- A feeling of mental or physical uneasiness, pain, or distress.

Contraindications
Acute intermittent porphyria as well as allergic or idiosyncratic reactions to carisoprodol or related compounds such as meprobamate, mebutamate, or tybamate.
Acute intermittent porphyria -- An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.

Warnings

Idiosyncratic Reactions: On very rare occasions, the first dose of carisoprodol has been followed by idiosyncratic symptoms appearing within minutes or hours.  Symptoms reported include: extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthria, agitation, euphoria, confusion, and disorientation.  Symptoms usually subside over the course of the next several hours.  Supportive and symptomatic therapy, including hospitalization, may be necessary. Usage in Pregnancy and Lactation: Safe usage of this drug in pregnancy or lactation has not been established.  Therefore, use of this drug in pregnancy, in nursing mothers, or in women of childbearing potential requires that the potential benefits of the drug be weighed against the potential hazards to mother and child.  Carisoprodol is present in breast milk of lactating mothers at concentrations two to four times that of maternal plasma.  This factor should be taken into account when use of the drug is contemplated in breast-feeding patients. Usage in children: Because of limited clinical experience, Carisoprodol is not recommended for use in patients under 12 years of age. Potentially Hazardous Tasks: Patients should be warned that this drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a motor vehicle or operating machinery.

Additive Effects: Since the effects of carisoprodol and alcohol or carisoprodol and other CNS depressants or psychotropic drugs may be additive, appropriate caution should be exercised with patients who take more than one of these agents simultaneously. Drug Dependence: In dogs, no withdrawal symptoms occurred after abrupt cessation of carisoprodol from dosages as high as 1 gm/kg/day.  In a study in man, abrupt cessation of 100 mg/kg/day (about five times the recommended daily adult dosage) was followed in some subjects by mild withdrawal symptoms such as abdominal cramps, insomnia, chilliness, headache, and nausea.  Delirium and convulsions did not occur.  In clinical use, psychological dependence and abuse have been rare, and there have been no reports of significant abstinence signs.  Nevertheless, the drug should be used with caution in addiction-prone individuals.
Branded Drugs
The following US Branded drugs contain Carisoprodol


CARISOPRODOL AND ASPIRIN -- ACTAVIS TOTOWA LLC

CARISOPRODOL AND ASPIRIN -- PAR PHARMACEUTICAL INC

CARISOPRODOL AND ASPIRIN -- SANDOZ INC

CARISOPRODOL COMPOUND -- WATSON LABORATORIES INC

SOMA COMPOUND -- MEDA PHARMACEUTICALS MEDA PHARMACEUTICALS INC

CARISOPRODOL, ASPIRIN AND CODEINE PHOSPHATE -- ACTAVIS TOTOWA LLC

CARISOPRODOL, ASPIRIN AND CODEINE PHOSPHATE -- SANDOZ INC

SOMA COMPOUND W/ CODEINE -- MEDA PHARMACEUTICALS MEDA PHARMACEUTICALS INC

SOMA -- MEDA PHARMACEUTICALS MEDA PHARMACEUTICALS INC

RELA -- SCHERING CORP SUB SCHERING PLOUGH CORP


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