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Basic Drug Info
Drug Name:Timolol Maleate
Manufacturer:Bausch & Lomb Incorporated
Other Info:Bausch & Lomb IncorporatedTampa, FL 33637┬ęBausch & Lomb Incorporated9071900 (Folded) 9072000 (Flat)



Clinical Trials:


Indications and Usage
Timolol maleate ophthalmic solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Intraocular pressure disorder --

Ocular Hypertension -- A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.

Open Angle Glaucoma -- Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.

Contraindications
Timolol maleate is contraindicated in patients with (1) bronchial asthma; (2) a history of bronchial asthma; (3) severe chronic obstructive pulmonary disease (see WARNINGS); (4) sinus bradycardia; (5) second or third degree atrioventricular block; (6) overt cardiac failure (see WARNINGS; (7) cardiogenic shock; or (8) hypersensitivity to any component of this product.
Asthma -- A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Heart failure -- inability of the heart to pump blood at an adequate rate to fill tissue metabolic requirements or the ability to do so only at an elevated filling pressure.

Cardiogenic shock -- Shock resulting from diminution of cardiac output in heart disease.

Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

As with many topically applied ophthalmic drugs, this drug is absorbed systemically.The same adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration.

For example, severerespiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, havebeen reported following systemic or ophthalmic administration of timolol maleate (see CONTRAINDICATIONS).
Branded Drugs
The following US Branded drugs contain Timolol Maleate


COMBIGAN -- ALLERGAN INC

COSOPT -- MERCK RESEARCH LABORATORIES DIV MERCK CO INC

DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE -- APOTEX INC

DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE -- HI TECH PHARMACAL CO INC

DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE -- SANDOZ INC

TIMOLIDE 10-25 -- MERCK AND CO INC

TIMOPTIC-XE -- ATON PHARMA INC

ISTALOL -- ISTA PHARMACEUTICALS

TIMOPTIC -- ATON PHARMA INC

TIMOPTIC IN OCUDOSE -- ATON PHARMA INC

BLOCADREN -- MERCK RESEARCH LABORATORIES DIV MERCK CO INC


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