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Basic Drug Info
Drug Name:hydroxyzine hydrochloride
Manufacturer:Actavis Totowa LLC
Other Info:



Clinical Trials:


Indications and Usage

For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested.Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses and in histamine-mediated pruritus.As a sedative when used as a premedication and following general anesthesia, hydroxyzine may potentiate meperidine and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis.

Atropine and other belladonna alkaloids are not affected by the drug.

Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent.The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, has not been assessed by systematic clinical studies.

The physician should reassess periodically the usefulness of the drug for the individual patient.
Pruritus -- An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Dermatologic disorders -- impairment of health or a condition of abnormal functioning of the skin.

Contraindications

Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit induced fetal abnormalities in the rat and mouse at doses substantially above the human therapeutic range.

Clinical data in human beings are inadequate to establish safety in early pregnancy.

Until such data are available, hydroxyzine is contraindicated in early pregnancy.Hydroxyzine is contraindicated for patients who have shown a previous hypersensitivity to it.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

Nursing Mothers: It is not known whether this drug is excreted in human milk.

Since many drugs are so excreted, hydroxyzine should not be given to nursing mothers.
Branded Drugs
The following US Branded drugs contain hydroxyzine hydrochloride


HYDROXYZINE -- BAXTER HEALTHCARE CORP ANESTHESIA AND CRITICAL CARE

ORGATRAX -- ORGANON USA INC

VISTARIL -- PFIZER LABORATORIES DIV PFIZER INC

ATARAX -- ROERIG DIV PFIZER INC

ATARAX -- PFIZER INC


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