Bisoprolol is indicated in the management of hypertension.

It may be used alone or in combination with other antihypertensive agents.

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Hypertensive disease -- Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Bisoprolol is contraindicated in patients with cardiogenic shock, overt cardiac failure, second or third degree AV block, and marked sinus bradycardia.

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Cardiogenic shock -- Shock resulting from diminution of cardiac output in heart disease.

Heart failure -- inability of the heart to pump blood at an adequate rate to fill tissue metabolic requirements or the ability to do so only at an elevated filling pressure.

Complete atrioventricular block -- Complete failure of atrial electrical impulse conduction through the AV node to the ventricles.

Sinus bradycardia -- A heart rate of less than 60 beats per minute, with its origin in the sinus node. (NCI)

Sympathetic stimulation is a vital component supporting circulatory function in the setting of congestive heart failure, and beta-blockade may result in further depression of myocardial contractility and precipitate more severe failure.

In general, beta-blocking agents should be avoided in patients with overt congestive failure.

However, in some patients with compensated cardiac failure it may be necessary to utilize them.

In such a situation, they must be used cautiously.

The following US Branded drugs contain bisoprolol fumarate

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ZEBETA -- DURAMED PHARMACEUTICALS INC SUB BARR LABORATORIES INC

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE -- ACTAVIS ELIZABETH LLC

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE -- APOTHECON INC DIV BRISTOL MYERS SQUIBB

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE -- IVAX PHARMACEUTICALS INC

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE -- MYLAN PHARMACEUTICALS INC

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE -- SANDOZ INC

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE -- TEVA PHARMACEUTICALS USA INC

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE -- WATSON LABORATORIES INC

ZIAC -- DURAMED PHARMACEUTICALS INC SUB BARR LABORATORIES INC