Basic Drug Info
Manufacturer:Mayne Pharma (USA) Inc.
Other Info:

Clinical Trials:

Indications and Usage

Bleomycin for Injection should be considered a palliative treatment.

It has been shown to be useful in the management of the following neoplasms either as a single agent or in proven combinations with other approved chemotherapeutic agents:
Neoplasms -- New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Bleomycin for Injection is contraindicated in patients who have demonstrated a hypersensitive or an idiosyncratic reaction to it.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.


Patients receiving bleomycin must be observed carefully and frequently during and after therapy.

It should be used with extreme caution in patients with significant impairment of renal function or compromised pulmonary function.Pulmonary toxicities occur in 10% of treated patients.

In approximately 1%, the nonspecific pneumonitis induced by bleomycin progresses to pulmonary fibrosis, and death.

Although this is age and dose related, the toxicity is unpredictable.

Frequent roentgenograms are recommended (see ADVERSE REACTIONS: Pulmonary).A severe idiosyncratic reaction (similar to anaphylaxis) consisting of hypotension, mental confusion, fever, chills, and wheezing has been reported in approximately 1% of lymphoma patients treated with bleomycin.

Since these reactions usually occur after the first or second dose, careful monitoring is essential after these doses (see ADVERSE REACTIONS: Idiosyncratic Reactions).Renal or hepatic toxicity, beginning as a deterioration in renal or liver function tests, have been reported, infrequently.

These toxicities may occur, however, at any time after initiation of therapy.

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