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Basic Drug Info
Drug Name:Oxybutynin Chloride
Manufacturer:Pharmaceutical Associates, Inc.
Other Info:



Clinical Trials:


Indications and Usage
Oxybutynin chloride syrup is indicated for the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria).
Symptoms -- An indication that a person has a condition or disease. Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.

Detrusor instability --

Extravasation of urine --

Urge Incontinence -- Involuntary discharge of URINE that is associated with an abrupt and strong desire to void. It is usually related to the involuntary contractions of the detrusor muscle of the bladder (detrusor hyperreflexia or detrusor instability).

Dysuria -- Painful URINATION. It is often associated with infections of the lower URINARY TRACT.

Contraindications

Oxybutynin chloride is contraindicated in patients with untreated angle closure glaucoma and in patients with untreated narrow anterior chamber angles since anticholinergic drugs may aggravate these conditions.

It is also contraindicated in partial or complete obstruction of the gastrointestinal tract, paralytic ileus, intestinal atony of the elderly or debilitated patient, megacolon, toxic megacolon complicating ulcerative colitis, severe colitis, and myasthenia gravis.

It is contraindicated in patients with obstructive uropathy and in patients with unstable cardiovascular status in acute hemorrhage.Oxybutynin chloride is contraindicated in patients who have demonstrated hypersensitivity to the product.
Angle Closure Glaucoma -- A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber.

Paralytic Ileus --

Megacolon -- Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.

Ulcerative Colitis -- Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.

Myasthenia Gravis -- A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)

Obstructive Uropathy --

Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

Oxybutynin chloride, when administered in the presence of high environmental temperature, can cause heat prostration (fever and heat stroke due to decreased sweating).Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy.

In this instance, treatment with oxybutynin chloride would be inappropriate and possibly harmful.Oxybutynin chloride may produce drowsiness or blurred vision.

The patient should be cautioned regarding activities requiring mental alertness such as operating a motor vehicle or other machinery or performing hazardous work while taking this drug.Alcohol or other sedative drugs may enhance the drowsiness caused by oxybutynin chloride.
Branded Drugs
The following US Branded drugs contain Oxybutynin Chloride


GELNIQUE -- WATSON LABORATORIES INC

DITROPAN -- ORTHO MCNEIL JANSSEN PHARMACEUTICALS INC

DITROPAN XL -- ORTHO MCNEIL JANSSEN PHARMACEUTICALS INC

OXYBUTYIN CHLORIDE -- OSMOTICA PHARMACEUTICAL CORP


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