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Basic Drug Info
Drug Name:Cantil
Manufacturer:sanofi-aventis U.S. LLC
Other Info:

Rev.

February 2006Manufactured for:sanofi-aventis U.S.

LLCBridgewater, NJ 08807



Clinical Trials:


Indications and Usage

CANTIL is indicated for use as adjunctive therapy in the treatment of peptic ulcer.

It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
Peptic Ulcer -- Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Complication -- Any disease or disorder that occurs during the course of (or because of) another disease.

Complication Aspects -- Used with diseases to indicate conditions that co-exist or follow, i.e., co-existing diseases, complications, or sequelae.

Contraindications
GlaucomaObstructive uropathy (for example, bladder neck obstruction due to prostatic hypertrophy)Obstructive disease of the gastrointestinal tract (for example, pyloroduodenal stenosis, achalasia)Paralytic ileusIntestinal atony of the elderly or debilitated patient (See PRECAUTIONS, Geriatric Use)Unstable cardiovascular status in acute gastrointestinal hemorrhageToxic megacolon complicating ulcerative colitisMyasthenia gravisAllergic or idiosyncratic reactions to CANTIL or related compounds
Urologic Diseases -- Pathological processes of the URINARY TRACT in both males and females.

Bladder neck obstruction -- Blocked urine flow through the bladder neck, the narrow internal urethral opening at the base of the URINARY BLADDER. Narrowing or strictures of the URETHRA can be congenital or acquired. It is often observed in males with enlarged PROSTATE GLAND.

Diseases, Obstructive --

Acquired stenosis --

Stenosis -- The condition of an anatomical structure's being constricted beyond normal dimensions.

Stenosis, unspecified --

Warnings

In the presence of high environmental temperature, heat prostration (fever and heat stroke due to decreased sweating) can occur with use of CANTIL.Diarrhea may be an early symptom of incomplete intestinal obstruction especially in patients with ileostomy or colostomy.

In this instance, treatment with this drug would be inappropriate and possibly harmful.CANTIL may produce drowsiness or blurred vision.

The patient should be cautioned regarding activities requiring mental alertness such as operating a motor vehicle or other machinery or performing hazardous work while taking this drug.With overdosage, a curare-like action may occur i.e., neuromuscular blockage leading to muscular weakness and possible paralysis.It should be noted that the use of anticholinergic drugs in the treatment of gastric ulcer may produce a delay in gastric emptying time and may complicate such therapy (antral stasis).Psychosis has been reported in sensitive individuals given anticholinergic drugs.

CNS signs and symptoms include confusion, disorientation, short-term memory loss, hallucinations, dysarthria, ataxia, coma, euphoria, decreased anxiety, fatigue, insomnia, agitation and mannerisms and inappropriate affect.

These CNS signs and symptoms usually resolve within 12 to 24 hours after discontinuation of the medication.

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