|Drug Name:||Inderal LA|
|Manufacturer:||Wyeth Pharmaceuticals, Inc.|
|Other Info:||The usual dosage is
80 to 160 mg Inderal LA once daily.|
Inderal LA is indicated
in the management of hypertension.
It may be used alone or used in
combination with other antihypertensive agents, particularly a thiazide
Inderal LA is not indicated in the management of hypertensive
-- Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Propranolol is contraindicated
in 1) cardiogenic shock; 2) sinus bradycardia and greater
than first-degree block; 3) bronchial asthma; and 4) in
patients with known hypersensitivity to propranolol hydrochloride.
-- A heart rate of less than 60 beats per minute, with its origin in the sinus node. (NCI)
-- A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
-- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
There have been reports
of exacerbation of angina and, in some cases, myocardial infarction,
following abrupt discontinuance of propranolol therapy.
when discontinuance of propranolol is planned, the dosage should
be gradually reduced over at least a few weeks, and the patient should
be cautioned against interruption or cessation of therapy without
the physician's advice.
If propranolol therapy is interrupted and
exacerbation of angina occurs, it usually is advisable to reinstitute
propranolol therapy and take other measures appropriate for the management
of unstable angina pectoris.
Since coronary artery disease may be
unrecognized, it may be prudent to follow the above advice in patients
considered at risk of having occult atherosclerotic heart disease
who are given propranolol for other indications.
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It should not to be used for self-diagnosis or treatment.