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Basic Drug Info
Drug Name:Zidovudine
Manufacturer:Roxane Laboratories, Inc.
Other Info:

There are insufficient data to recommend dose adjustment of zidovudine in patients with mild to moderate impaired hepatic function or liver cirrhosis.

Since zidovudine is primarily eliminated by hepatic metabolism, a reduction in the daily dose may be necessary in these patients.

Frequent monitoring for hematologic toxicities is advised (see CLINICAL PHARMACOLOGY: Pharmacokinetics and PRECAUTIONS: General).



Clinical Trials:


Indications and Usage
Zidovudine Tablets, USP in combination with other antiretroviral agents is indicated for the treatment of HIV infection.
HIV Infections -- any state of infection accompanied by evidence of HIV in the body (positive test for HIV genome, cDNA, proteins, antigens, or antibodies); may be medically asymptomatic or symptomatic; use AIDS when appropriate.

Contraindications
Zidovudine Tablets are contraindicated for patients who have potentially life-threatening allergic reactions to any of the components of the formulation.
Allergic Reaction --

Warnings

COMBIVIRCOMBIVIR® is a registered trademark of GlaxoSmithKline.

and TRIZIVIRTRIZIVIR® is a registered trademark of GlaxoSmithKline.

are combination product tablets that contain zidovudine as one of their components.

Zidovudine should not be administered concomitantly with COMBIVIR or TRIZIVIR.The incidence of adverse reactions appears to increase with disease progression; patients should be monitored carefully, especially as disease progression occurs.
Branded Drugs
The following US Branded drugs contain Zidovudine


TRIZIVIR -- GLAXOSMITHKLINE

COMBIVIR -- GLAXOSMITHKLINE

RETROVIR -- GLAXOSMITHKLINE


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