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Basic Drug Info
Drug Name:Glipizide
Manufacturer:CARACO PHARMACEUTICAL LABORATORIES, LTD.
Other Info:



Clinical Trials:


Indications and Usage

Glipizide tablets are indicated as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM;type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.In initiating treatment for non-insulin-dependent diabetes, diet should be emphasized as the primary form of treatment.

Caloric restriction and weight loss are essential in the obese diabetic patient.

Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia.

The importance of regular physical activity should also be stressed, and cardiovascular risk factors should be identified, and corrective measures taken where possible.

If this treatment program fails to reduce symptoms and/or blood glucose, the use of an oral sulfonylurea or insulin should be considered.

Use of Glipizide tablets must be viewed by both the physician and patient as a treatment in addition to diet, and not as a substitute for diet or as a convenient mechanism for avoiding dietary restraint.

Furthermore, loss of blood glucose control on diet alone also may be transient, thus requiring only short-term administration of Glipizide tablets. During maintenance programs, Glipizide tablets should be discontinued if satisfactory lowering of blood glucose is no longer achieved.

Judgments should be based on regular clinical and laboratory evaluations.In considering the use of Glipizide tablets in asymptomatic patients, it should be recognized that controlling the blood glucose in non-insulin-dependent diabetes has not been definitely established to be effective in preventing the long-term cardiovascular or neural complications of diabetes.
Hyperglycemia -- Abnormally high BLOOD GLUCOSE level.

Diabetes Mellitus, Non-Insulin-Dependent -- subclass of diabetes mellitus that is not insulin responsive or dependent; characterized initially by insulin resistance and hyperinsulinemia and eventually by glucose intolerance, hyperglycemia, and overt diabetes; type II diabetes mellitus is no longer considered a disease exclusively found in adults; patients seldom develop ketosis but often exhibit obesity.

Symptoms -- An indication that a person has a condition or disease. Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.

Complication -- Any disease or disorder that occurs during the course of (or because of) another disease.

Complication Aspects -- Used with diseases to indicate conditions that co-exist or follow, i.e., co-existing diseases, complications, or sequelae.

Diabetes --

Diabetes Mellitus -- A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Contraindications

Glipizide tablets are contraindicated in patients with:Known hypersensitivity to the drug.Diabetic ketoacidosis, with or without coma.

This condition should be treated with insulin.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Diabetic Ketoacidosis -- A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by excessive LIPOLYSIS, oxidation of FATTY ACIDS, production of KETONE BODIES, a sweet smell to the breath (KETOSIS;) DEHYDRATION; and depressed consciousness leading to COMA.

comatose -- A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Branded Drugs
The following US Branded drugs contain Glipizide


GLUCOTROL XL -- PFIZER INC

GLUCOTROL -- PFIZER INC

GLIPIZIDE AND METFORMIN HYDROCHLORIDE -- CARACO PHARMACEUTICAL LABORATORIES LTD

GLIPIZIDE AND METFORMIN HYDROCHLORIDE -- COREPHARMA LLC

GLIPIZIDE AND METFORMIN HYDROCHLORIDE -- MYLAN PHARMACEUTICALS INC

GLIPIZIDE AND METFORMIN HYDROCHLORIDE -- TEVA PHARMACEUTICALS USA

METAGLIP -- BRISTOL MYERS SQUIBB CO


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