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Basic Drug Info
Drug Name:Clorazepate Dipotassium
Manufacturer:Mylan Pharmaceuticals Inc.
Other Info:Mylan Pharmaceuticals Inc.Morgantown, WV 26505REVISED OCTOBER 2004CZPT:R16T



Clinical Trials:


Indications and Usage

Clorazepate dipotassium tablets are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.

Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.Clorazepate dipotassium tablets are indicated as adjunctive therapy in the management of partial seizures.The effectiveness of clorazepate dipotassium tablets in long-term management of anxiety, that is, more than 4 months, has not been assessed by systematic clinical studies.

Long-term studies in epileptic patients, however, have shown continued therapeutic activity.

The physician should reassess periodically the usefulness of the drug for the individual patient.Clorazepate dipotassium tablets are indicated for the symptomatic relief of acute alcohol withdrawal.
Symptoms -- An indication that a person has a condition or disease. Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.

Partial Seizure -- any seizure due to a lesion in a specific, known area of the cerebral cortex; symptoms vary with different lesion locations.

Contraindications
Clorazepate dipotassium tablets are contraindicated in patients with a known hypersensitivity to the drug and in those with acute narrow angle glaucoma.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Angle Closure Glaucoma -- A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber.

Warnings
Clorazepate dipotassium tablets are not recommended for use in depressive neuroses or in psychotic reactions.Patients taking clorazepate dipotassium tablets should be cautioned against engaging in hazardous occupations requiring mental alertness, such as operating dangerous machinery including motor vehicles.Since clorazepate dipotassium has a central nervous system depressant effect, patients should be advised against the simultaneous use of other CNS-depressant drugs, and cautioned that the effects of alcohol may be increased.Because of the lack of sufficient clinical experience, clorazepate dipotassium tablets are not recommended for use in patients less than 9 years of age.
Branded Drugs
The following US Branded drugs contain Clorazepate Dipotassium


TRANXENE -- LUNDBECK INC

GEN-XENE -- ALRA LABORATORIES INC

TRANXENE SD -- LUNDBECK INC


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