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Basic Drug Info
Drug Name:Lincocin
Manufacturer:Pharmacia and Upjohn Company
Other Info:Rx onlyLAB-0138-4.0June 2007



Clinical Trials:


Indications and Usage

LINCOCIN Sterile Solution is indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci.

Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate.

Because of the risk of antibiotic-associated pseudomembranous colitis, as described in the WARNING box, before selecting lincomycin the physician should consider the nature of the infection and the suitability of less toxic alternatives (eg, erythromycin).Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to lincomycin.Indicated surgical procedures should be performed in conjunction with antibiotic therapy.Lincomycin has been demonstrated to be effective in the treatment of staphylococcal infections resistant to other antibiotics and susceptible to lincomycin.

Staphylococcal strains resistant to LINCOCIN have been recovered; culture and susceptibility studies should be done in conjunction with therapy with LINCOCIN.

In the case of macrolides, partial but not complete cross resistance may occur (see Microbiology).

The drug may be administered concomitantly with other antimicrobial agents when indicated.Lincomycin is not indicated in the treatment of minor bacterial infections or viral infections.To reduce the development of drug-resistant bacteria and maintain the effectiveness of LINCOCIN and other antibacterial drugs, LINCOCIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.

In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Infection -- Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.

Unspecified Staphylococcus infection in conditions classified elsewhere and of unspecified site --

Communicable Diseases -- broad class of diseases whose causative agents may be passed between individuals in many different ways.

Staphylococcal Infections -- Infections with bacteria of the genus STAPHYLOCOCCUS.

Bacterial Infections -- Infections by bacteria, general or unspecified.

Virus Diseases -- A general term for diseases produced by viruses.

Contraindications
This drug is contraindicated in patients previously found to be hypersensitive to lincomycin or clindamycin.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Lincomycin, and may range in severity from mild diarrhea to fatal colitis.

Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C.

difficile.C.

difficile produces toxins A and B which contribute to the development of CDAD.

Hypertoxin producing strains of C.

difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy.

CDAD must be considered in all patients who present with diarrhea following antibiotic use.

Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C.

difficile may need to be discontinued.

Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C.

difficile, and surgical evaluation should be instituted as clinically indicated.

Other causes of colitis should also be considered.

A careful inquiry should be made concerning previous sensitivities to drugs and other allergens.LINCOCIN Sterile Solution contains benzyl alcohol as a preservative.

Benzyl alcohol has been associated with a fatal "Gasping Syndrome" in premature infants.Usage in Meningitis — Although lincomycin appears to diffuse into cerebrospinal fluid, levels of lincomycin in the CSF may be inadequate for the treatment of meningitis.SERIOUS ANAPHYLACTOID REACTIONS REQUIRE IMMEDIATE EMERGENCY TREATMENT WITH EPINEPHRINE.

OXYGEN AND INTRAVENOUS CORTICOSTEROIDS SHOULD ALSO BE ADMINISTERED AS INDICATED.

(See ADVERSE REACTIONS.)

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