Pharmacokinetics:In vitro and in vivo bioavailability studies have demonstrated that naftifine penetrates the stratum corneum in sufficient concentration to inhibit the growth of dermatophytes.Following a single topical application of 1% naftifine cream to the skin of healthy subjects, systemic absorption of naftifine was approximately 6% of the applied dose.
Naftifine and/or its metabolites are excreted via the urine and feces with a half-life of approximately two to three days.
Naftin® Cream, 1% is indicated for the topical treatment of tinea pedis, tinea cruris and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
-- Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.
Tinea corporis (disorder)
Naftin® Cream, 1% is contraindicated in individuals who have shown hypersensitivity to any of its components.
-- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Naftin® Cream, 1% is for topical use only and not for ophthalmic use.
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