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Basic Drug Info
Drug Name:Orphenadrine Citrate
Manufacturer:Watson Laboratories, Inc.
Other Info:



Clinical Trials:


Indications and Usage

Orphenadrine citrate is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculo-skeletal conditions.

The mode of action of this drug has not been clearly identified, but may be related to its analgesic properties.

Orphenadrine citrate does not directly relax tense skeletal muscles in man.
Sensory Discomfort -- A feeling of mental or physical uneasiness, pain, or distress.

Contraindications
Orphenadrine citrate is contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, prostatic hypertrophy or obstruction at the bladder neck, cardiospasm (megaesophagus) and myasthenia gravis.Orphenadrine citrate is contraindicated in patients who have demonstrated a previous hypersensitivity to the drug.
Glaucoma -- An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Duodenal Obstruction -- Hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents.

Stenosis -- The condition of an anatomical structure's being constricted beyond normal dimensions.

Peptic Ulcer -- Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Prostatic hypertrophy --

Megaesophagus --

Myasthenia Gravis -- A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)

Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

Contains Sodium Metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people.

The overall prevalence of sulfite sensitivity in the general population is unknown and probably low.

Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.Some patients may experience transient episodes of lightheadedness, dizziness or syncope.Orphenadrine citrate may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; ambulatory patients should therefore be cautioned accordingly.
Branded Drugs
The following US Branded drugs contain Orphenadrine Citrate


INVAGESIC -- SANDOZ INC

INVAGESIC FORTE -- SANDOZ INC

NORGESIC -- GRACEWAY PHARMACEUTICALS LLC

NORGESIC FORTE -- GRACEWAY PHARMACEUTICALS LLC

ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE -- SANDOZ INC

ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE -- JEROME STEVENS PHARMACEUTICALS INC

ORPHENGESIC -- SOLCO HEALTHCARE US LLC

ORPHENGESIC FORTE -- SOLCO HEALTHCARE US LLC

NORFLEX -- GRACEWAY PHARMACEUTICALS LLC


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