IMITREX Injection should not be
given intravenously because of its potential to cause coronary vasospasm. IMITREX Injection
should not be given to patients with history, symptoms, or signs of ischemic
cardiac, cerebrovascular, or peripheral vascular syndromes.
In addition, patients
with other significant underlying cardiovascular diseases should not receive
Ischemic cardiac syndromes include, but are not limited
to, angina pectoris of any type (e.g., stable angina of effort and vasospastic
forms of angina such as the Prinzmetal variant), all forms of myocardial infarction,
and silent myocardial ischemia.
Cerebrovascular syndromes include, but are
not limited to, strokes of any type as well as transient ischemic attacks.
Peripheral vascular disease includes, but is not limited to, ischemic bowel
disease (see WARNINGS: Other Vasospasm-Related Events and WARNINGS: Risk of
Myocardial Ischemia and/or Infarction and Other Adverse Cardiac Events).
Injection may increase blood pressure, it should not be given to patients
with uncontrolled hypertension. IMITREX
Injection and any ergotamine-containing or ergot-type medication (like dihydroergotamine
or methysergide) should not be used within 24 hours of each other, nor
should IMITREX Injection and another 5-HT1 agonist. IMITREX Injection should not be administered to patients
with hemiplegic or basilar migraine. IMITREX Injection is contraindicated in patients with hypersensitivity
to sumatriptan or any of its components. IMITREX Injection is contraindicated in patients with severe
Coronary Artery Vasospasm
-- Spasm of the large- or medium-sized coronary arteries.
-- An indication that a person has a condition or disease. Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.
-- Objective evidence of disease perceptible to the examining physician.
-- A symptom complex of unknown etiology, that is characteristic of a particular abnormality.
-- Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
-- The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
SPONDYLOMETAEPIPHYSEAL DYSPLASIA, SHORT LIMB-HAND TYPE
-- Angina pectoris which has not recently changed in frequency, duration or intensity. Stable angina pectoris is relieved by rest or administration or oral, sublingual or transdermal antianginal medications.
-- NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
-- sudden neurologic impairment due to a cerebrovascular disorder, either an arterial occlusion or an intracranial hemorrhage.
Transient Ischemic Attack
-- Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Peripheral Vascular Diseases
-- Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
Gastrointestinal tract vascular insufficiency
-- A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
-- Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.
-- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.