HypertensionAtenolol tablets are indicated in the management of hypertension.

They may be used alone or concomitantly with other antihypertensive agents, particularly with a thiazide-type diuretic.Angina Pectoris Due to Coronary AtherosclerosisAtenolol tablets are indicated for the long-term management of patients with angina pectoris.Acute Myocardial InfarctionAtenolol tablets are indicated in the management of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality.

Treatment can be initiated as soon as the patient’s clinical condition allows.

(See DOSAGE AND ADMINISTRATION, CONTRAINDICATIONS, and WARNINGS.) In general, there is no basis for treating patients like those who were excluded from the ISIS-1 trial (blood pressure less than 100 mm Hg systolic, heart rate less than 50 bpm) or have other reasons to avoid beta blockade.

As noted above, some subgroups (e.g., elderly patients with systolic blood pressure below 120 mm Hg) seemed less likely to benefit.

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Hypertensive disease -- Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Angina Pectoris -- The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.

Acute myocardial infarction --

Atenolol tablets are contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure.

(See WARNINGS.)Atenolol tablets are contraindicated in those patients with a history of hypersensitivity to the atenolol or any of the drug product’s components.

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Sinus bradycardia -- A heart rate of less than 60 beats per minute, with its origin in the sinus node. (NCI)

Heart Block -- Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.

Cardiogenic shock -- Shock resulting from diminution of cardiac output in heart disease.

Heart failure -- inability of the heart to pump blood at an adequate rate to fill tissue metabolic requirements or the ability to do so only at an elevated filling pressure.

Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Sympathetic stimulation is necessary in supporting circulatory function in congestive heart failure, and beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe failure.

In patients who have congestive heart failure controlled by digitalis and/or diuretics, atenolol should be administered cautiously.

Both digitalis and atenolol slow AV conduction.In patients with acute myocardial infarction, cardiac failure which is not promptly and effectively controlled by 80 mg of intravenous furosemide or equivalent therapy is a contraindication to beta blocker treatment.

The following US Branded drugs contain Atenolol

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TENORMIN -- ASTRAZENECA PHARMACEUTICALS LP

TENORMIN -- ASTRAZENECA LP

ATENOLOL AND CHLORTHALIDONE -- IPR PHARMACEUTICALS INC

ATENOLOL AND CHLORTHALIDONE -- MUTUAL PHARMACEUTICAL CO INC

ATENOLOL AND CHLORTHALIDONE -- MYLAN PHARMACEUTICALS INC

ATENOLOL AND CHLORTHALIDONE -- NOSTRUM LABORATORIES INC

ATENOLOL AND CHLORTHALIDONE -- PLIVA INC

ATENOLOL AND CHLORTHALIDONE -- WATSON LABORATORIES INC

TENORETIC 100 -- ASTRAZENECA PHARMACEUTICALS LP

TENORETIC 50 -- ASTRAZENECA PHARMACEUTICALS LP