|Drug Name:||Hydromorphone Hydrochloride|
Hydromorphone hydrochloride tablets pose little risk of direct exposure to health care personnel and should be handled and disposed of prudently in accordance with hospital or institutional policy.
Significant absorption from dermal exposure is unlikely.
Patients and their families should be instructed to flush any hydromorphone hydrochloride tablets that are no longer needed.Access to abuseable drugs such as hydromorphone hydrochloride tablets presents an occupational hazard for addiction in the health care industry.
Routine procedures for handling controlled substances developed to protect the public may not be adequate to protect health care workers.Implementation of more effective accounting procedures and measures to restrict access to drugs of this class (appropriate to the practice setting) may minimize the risk of self-administration by health care providers.
Hydromorphone hydrochloride tablets are contraindicated in: patients with known hypersensitivity to hydromorphone, patients with respiratory depression in the absence of resuscitative equipment, and in patients with status asthmaticus.Hydromorphone hydrochloride tablets are also contraindicated for use in obstetrical analgesia.
Respiratory Depression– Respiratory depression is the chief hazard of hydromorphone hydrochloride tablets.
Respiratory depression is more likely to occur in the elderly, in the debilitated, and in those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.Hydromorphone hydrochloride tablets should be used with extreme caution in patients with chronic obstructive pulmonary disease or cor pulmonale, patients having a substantially decreased respiratory reserve, hypoxia, hypercapnia, or in patients with preexisting respiratory depression.
In such patients even usual therapeutic doses of opioid analgesics may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea.Hydromorphone hydrochloride tablets contain hydromorphone, which is a potent Schedule II controlled opioid agonist.
Schedule II opioid agonists, including morphine, oxymorphone, oxycodone, fentanyl, and methadone, have the highest potential for abuse and risk of producing respiratory depression.Alcohol, other opioids and central nervous system depressants (sedative-hypnotics) potentiate the respiratory depressant effects of hydromorphone, increasing the risk of respiratory depression that might result in death.