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Basic Drug Info
Drug Name:Sodium Polystyrene Sulfonate
Manufacturer:Roxane Laboratories
Other Info:

Sodium polystyrene sulfonate suspension may also be given, although with less effective results, as an enema consisting (for adults) of 30 g (120 mL) to 50 g (200 mL) every six hours.

The enema should be retained as long as possible and followed by a cleansing enema.After an initial cleansing enema, a soft, large size (French 28) rubber tube is inserted into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and taped in place.

The suspension is introduced at body temperature by gravity.

The suspension is flushed with 50 mL or 100 mL of fluid, following which the tube is clamped and left in place.

If back leakage occurs, the hips are elevated on pillows or a knee-chest position is taken temporarily.

The suspension is kept in the sigmoid colon for several hours, if possible.

Then, the colon is irrigated with a nonsodium containing solution at body temperature in order to remove the resin.

Two quarts of flushing solution may be necessary.

The returns are drained constantly through a Y tube connection.



Clinical Trials:


Indications and Usage
Sodium Polystyrene Sulfonate Suspension, USP is indicated for the treatment of hyperkalemia.
Contraindications
Sodium Polystyrene Sulfonate Suspension, USP is contraindicated in the following conditions: patients with hypokalemia, patients with a history of hypersensitivity to polystyrene sulfonate resins, obstructive bowel disease, neonates with reduced gut motility (postoperatively or drug induced) and oral administration in neonates (see PRECAUTIONS: Pediatric Use).
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Diseases, Obstructive --

Unspecified disorder of intestine -- Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.

Warnings

Since effective lowering of serum potassium with sodium polystyrene sulfonate may take hours to days, treatment with this drug alone may be insufficient to rapidly correct severe hyperkalemia associated with states of rapid tissue breakdown (e.g., burns and renal failure) or hyperkalemia so marked as to constitute a medical emergency.

Therefore, other definitive measures, including dialysis, should always be considered and may be imperative.
Branded Drugs
The following US Branded drugs contain Sodium Polystyrene Sulfonate


KALEXATE -- KVK TECH INC

KAYEXALATE -- SANOFI AVENTIS US LLC

KIONEX -- PADDOCK LABORATORIES INC

SPS -- CAROLINA MEDICAL PRODUCTS CO


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