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Basic Drug Info
Drug Name:Hydralazine HCl and Hydrochlorothiazide
Manufacturer:Par Pharmaceutical, Inc.
Other Info:



Clinical Trials:


Indications and Usage
Hypertension (see boxed WARNING).
Hypertensive disease -- Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Contraindications
HydralazineHypersensitivity to hydralazine; coronary artery disease; mitral valvular rheumatic heart disease.HydrochlorothiazideAnuria; hypersensitivity to this or other sulfonamide-derived drugs.
Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Warnings

HydralazineIn a few patients hydralazine may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis.

In such patients hydralazine should be discontinued unless the benefit-to-risk determination requires continued antihypertensive therapy with this drug.

Signs and symptoms usually regress when the drug is discontinued, but residua have been detected many years later.

Long-term treatment with steroids may be necessary.

(SeePRECAUTIONS, Laboratory Tests.)HydrochlorothiazideThiazides should be used with caution in patients with severe renal disease.

In patients with renal disease, thiazides may precipitate azotemia.

Cumulative effects of the drug may develop in patients with impaired renal function.Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte imbalance may precipitate hepatic coma.Thiazides may add to or potentiate the action of other antihypertensive drugs.

Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.Sensitivity reactions are more likely to occur in patients with a history of allergy or bronchial asthma.The possibility of exacerbation or activation of systemic lupus erythematosus has been reported.

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