HydralazineIn a few patients hydralazine may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis.
In such patients hydralazine should be discontinued unless the benefit-to-risk determination requires continued antihypertensive therapy with this drug.
Signs and symptoms usually regress when the drug is discontinued, but residua have been detected many years later.
Long-term treatment with steroids may be necessary.
(SeePRECAUTIONS, Laboratory Tests.)HydrochlorothiazideThiazides should be used with caution in patients with severe renal disease.
In patients with renal disease, thiazides may precipitate azotemia.
Cumulative effects of the drug may develop in patients with impaired renal function.Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte imbalance may precipitate hepatic coma.Thiazides may add to or potentiate the action of other antihypertensive drugs.Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.Sensitivity reactions are more likely to occur in patients with a history of allergy or bronchial asthma.The possibility of exacerbation or activation of systemic lupus erythematosus has been reported.