Basic Drug Info
Drug Name:Anturane
Manufacturer:Ciba-Geigy Corporation
Other Info:

400 mg daily, given in two divided doses, as above.

This dosage may be increased to 800 mg daily, if necessary, and may sometimes be reduced to as low as 200 mg daily after the blood urate level has been controlled.

Treatment should be continued without interruptian even in the presence of acute exacerbations, which can be concomitantly treated with phenylbutazone or colchicine.

Patients previously controlled with other uricosuric therapy may be transferred to Anturane at full maintenance dosage.

Clinical Trials:

Indications and Usage
Anturane is indicated for the treatment of: Chronic gouty arthritis Intermittent gouty arthritis
Gouty Arthritis -- Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.


Patients with an active peptic ulcer or symptoms of gastrointestinal inflammation or ulceration should not receive the drug.

      The drug is contraindicated in patients with a history or the presence of: Hypersensitivity to phenylbutazone or other pyrazoles Blood dyscrasias
Active Peptic Ulcer --

Symptoms -- An indication that a person has a condition or disease. Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.

Ulcer -- A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Hypersensitivity -- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Hematological Disease -- Disorders of the blood and blood forming tissues.


Studies on the teratogenicity of pyrazole compounds in animals have yielded inconclusive results.

Up to the present time, however, there have been no reported cases of human congenital malformation proved to be due to the use of the drug.      It is suggested that Anturane be used with caution in pregnant women, weighing the potential risks against the possible benefits.

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