|Manufacturer:||Merck & Co., Inc.|
Beta-adrenergic blocking agents may mask certain
clinical signs (e.g., tachycardia) of hyperthyroidism.
of developing thyrotoxicosis should be managed carefully to avoid
abrupt withdrawal of beta-adrenergic blocking agents that might precipitate
a thyroid storm.
Preservative-free TIMOPTIC in OCUDOSE is indicated
in the treatment of elevated intraocular pressure in patients with
ocular hypertension or open-angle glaucoma.Preservative-free TIMOPTIC in OCUDOSE may be used when a patient
is sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic
solution), benzalkonium chloride, or when use of a preservative-free
topical medication is advisable.
Intraocular pressure disorder
-- A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
Open Angle Glaucoma
-- Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.
Preservative-free TIMOPTIC in OCUDOSE is contraindicated
in patients with (1) bronchial asthma; (2) a history of bronchial
asthma; (3) severe chronic obstructive pulmonary disease (see WARNINGS); (4) sinus bradycardia; (5)
second or third degree atrioventricular block; (6) overt cardiac failure
(see WARNINGS); (7) cardiogenic shock; or (8)
hypersensitivity to any component of this product.
-- A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
-- inability of the heart to pump blood at an adequate rate to fill tissue metabolic requirements or the ability to do so only at an elevated filling pressure.
-- Shock resulting from diminution of cardiac output in heart disease.
-- Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
As with many topically applied ophthalmic drugs,
this drug is absorbed systemically.The same adverse reactions
found with systemic administration of beta-adrenergic blocking agents
may occur with topical administration.
For example, severe respiratory
reactions and cardiac reactions, including death due to bronchospasm
in patients with asthma, and rarely death in association with cardiac
failure, have been reported following systemic or ophthalmic administration
of timolol maleate (see CONTRAINDICATIONS).
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It should not to be used for self-diagnosis or treatment.