Overview

Name: Acute Myeloid Leukemia

Description: AML

This casebook is published and has been read 119 times.

The author of this casebook has identified the following medical topics as being highly relevant to this casebook.

• Acute Myeloid Leukemia with Recurrent Genetic Abnormalities -- A group of acute myeloid leukemias (AMLs) characterized by recurrent genetic abnormalities, mainly balanced translocations. This group of AMLs often has a high rate of complete remission, and favorable prognosis. (WHO, 2001) -- 2003
  
  
• Acute Myeloid Leukemia with Multilineage Dysplasia -- An acute myeloid leukemia (AML) with at least 20% blasts in the marrow or blood, and dysplasia in 2 or more myeloid cell lines. Dysplasia must be present in at least 50% of the cells of at least 2 cell lines. Patients with this type of AML often present with severe cytopenia. The presence of multilineage dysplasia has an adverse effect on the probability of achieving complete remission. (WHO, 2001)
  
  
• Acute Myeloid Leukemia not Otherwise Categorized -- This category of acute myeloid leukemias is morphology based and reflects the morphologic subtypes present in the French-American-British (FAB) classification scheme. (WHO, 2001) -- 2003
  
  
• Acute Myeloid Leukemia with 11q23 (MLL) Abnormalities -- An acute myeloid leukemia (AML) usually associated with monocytic features. Patients may present with disseminated intravascular coagulation. This AML has an intermediate survival rate. (WHO, 2001)
  
  
• Acute Myeloid Leukemia, Minimally Differentiated -- An acute myeloid leukemia (AML) in which the blasts do not show evidence of myeloid differentiation by morphology and conventional cytochemistry. The myeloid origin of the blasts is demonstrated by immunohistochemistry and/or electron microscopic studies. The patients present with anemia, neutropenia, and thrombocytopenia. The prognosis is usually poor. (WHO, 2001)
  
  
• Acute Myeloid Leukemia with Abnormal Marrow Eosinophils -- An acute myeloid leukemia (AML) with inv(16)(p13q22) or t(16;16)(p13;q22);(CBF-beat/MYH11). This AML shows monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow. This type of AML has a favorable prognosis. (WHO, 2001)
  
  
• recurrent adult acute myeloid leukemia -- The reemergence of acute myeloid leukemia in adults after a period of remission.
  
  
• Acute Myeloid Leukemia, M1 -- An acute myeloid leukemia (AML) characterized by blasts without evidence of maturation to more mature neutrophils. The patients present with anemia, neutropenia, and thrombocytopenia. This type of AML usually follows an aggressive clinical course. (WHO, 2001)
  
  
• Acute Myeloid Leukemia with Multilineage Dysplasia following Myelodysplastic Syndrome -- A subtype of acute myeloid leukemia with multilineage dysplasia. This subtype includes the vast majority of refractory anemia with excess blasts in transformation cases. This latter term used to be part of the French-American-British classification scheme of myelodysplastic syndromes and has been eliminated from the WHO classification. (WHO, 2001) -- 2003
  
  
• Acute Myeloid Leukemia in Remission -- Acute myeloid leukemia not growing, responding to treatment.
  
  
• Acute Myeloid Leukemia (AML-M2) -- An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation to more mature neutrophils. Patients often present with anemia, neutropenia, and thrombocytopenia. AML with the t(8;21) is usually AML with maturation. This type of AML frequently responds to aggressive therapy. (WHO, 2001)
  
  
• Acute Myeloid Leukemia with t(8;21)(q22;q22)(AML1(CBFa)/ETO) -- An acute myeloid leukemia (AML) showing maturation in the neutrophil lineage. The bone marrow and the peripheral blood show large myeloblasts with abundant basophilic cytoplasm, often containing azurophilic granules. This type of AML is associated with good response to chemotherapy and high complete remission rate. (WHO, 2001)
  
  

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